Delete user profile on Windows 7 domain computer

01. You can do it with the User Profiles dialog in System Properties:
Properites for Computer -> Advanced system settings (on the left side) -> Settings for User Profiles (in the middle) -> Select the profile you want to delete and click the delete button.

02. To clear user local profile via registry :
1.Press on Start > Run >Regedit
2.Navigate to the following registry key :“HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList”
3.Under ProfileList navigate to  binary key’s like this :S-1-5-21-3656904587-1668747452-4095529-500
4.On the right side under  ProfileImagePath you’’ll see the username and profile path.
5.Chose the one with the desired user and delete the long reg key like :“HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList”